Fifth Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup: recurrent disease.
Identifieur interne : 000C23 ( Main/Exploration ); précédent : 000C22; suivant : 000C24Fifth Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup: recurrent disease.
Auteurs : M K Wilson ; E. Pujade-Lauraine [France] ; D. Aoki [Japon] ; M R Mirza ; D. Lorusso [Italie] ; A M Oza [Canada] ; A. Du Bois [Allemagne] ; I. Vergote ; A. Reuss [Allemagne] ; M. Bacon [Canada] ; M. Friedlander ; D. Gallardo-Rincon [Mexique] ; F. Joly [France] ; S-J Chang [Corée du Sud] ; A M Ferrero [Italie] ; R J Edmondson [Royaume-Uni] ; P. Wimberger [Allemagne] ; J. Maenpaa ; D. Gaffney [États-Unis] ; R. Zang [République populaire de Chine] ; A. Okamoto [Japon] ; G. Stuart [Canada] ; K. Ochiai [Japon]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs de l'ovaire.
- Femelle, Humains, Plan de recherche, Récidive tumorale locale, Tumeurs de l'ovaire.
English descriptors
- KwdEn :
- MESH :
- pathology : Ovarian Neoplasms.
- therapy : Neoplasm Recurrence, Local, Ovarian Neoplasms.
- Female, Humans, Research Design.
Abstract
This manuscript reports the consensus statements regarding recurrent ovarian cancer (ROC), reached at the fifth Ovarian Cancer Consensus Conference (OCCC), which was held in Tokyo, Japan, in November 2015. Three important questions were identified: (i) What are the subgroups for clinical trials in ROC? The historical definition of using platinum-free interval (PFI) to categorise patients as having platinum-sensitive/resistant disease was replaced by therapy-free interval (TFI). TFI can be broken down into TFIp (PFI), TFInp (non-PFI) and TFIb (biological agent-free interval). Additional criteria to consider include histology, BRCA mutation status, number/type of previous therapies, outcome of prior surgery and patient reported symptoms. (ii) What are the control arms for clinical trials in ROC? When platinum is considered the best option, the control arm should be a platinum-based therapy with or without an anti-angiogenic agent or a poly (ADP-ribose) polymerase (PARP) inhibitor. If platinum is not considered the best option, the control arm could include a non-platinum drug, either as single agent or in combination. (iii) What are the endpoints for clinical trials in ROC? Overall survival (OS) is the preferred endpoint for patient cohorts with an expected median OS < or = 12 months. Progression-free survival (PFS) is an alternative, and it is the preferred endpoint when the expected median OS is > 12 months. However, PFS alone should not be the only endpoint and must be supported by additional endpoints including pre-defined patient reported outcomes (PROs), time to second subsequent therapy (TSST), or time until definitive deterioration of quality of life (TUDD).
DOI: 10.1093/annonc/mdw663
PubMed: 27993805
Affiliations:
- Allemagne, Canada, Corée du Sud, France, Italie, Japon, Mexique, Royaume-Uni, République populaire de Chine, États-Unis
- District de Dresde, Piémont, Région de Kantō, Saxe (Land), Île-de-France
- Dresde, Paris, Tokyo, Turin
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Le document en format XML
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Pujade-Lauraine</name><affiliation wicri:level="3"><nlm:affiliation>GINECO, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GINECO, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aoki, D" sort="Aoki, D" uniqKey="Aoki D" first="D" last="Aoki">D. Aoki</name><affiliation wicri:level="3"><nlm:affiliation>JGOG, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>JGOG, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Mirza, M R" sort="Mirza, M R" uniqKey="Mirza M" first="M R" last="Mirza">M R Mirza</name><affiliation><nlm:affiliation>NSGO, Copenhagen, Scandinavia.</nlm:affiliation><wicri:noCountry code="subField">Scandinavia</wicri:noCountry></affiliation></author><author><name sortKey="Lorusso, D" sort="Lorusso, D" uniqKey="Lorusso D" first="D" last="Lorusso">D. Lorusso</name><affiliation wicri:level="1"><nlm:affiliation>MITO, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MITO, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Oza, A M" sort="Oza, A M" uniqKey="Oza A" first="A M" last="Oza">A M Oza</name><affiliation wicri:level="1"><nlm:affiliation>PMHC, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PMHC, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Du Bois, A" sort="Du Bois, A" uniqKey="Du Bois A" first="A" last="Du Bois">A. Du Bois</name><affiliation wicri:level="1"><nlm:affiliation>AGO, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>AGO, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name><affiliation><nlm:affiliation>BGOG, Leuven, Kingdom of Belgium.</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Belgium</wicri:noCountry></affiliation></author><author><name sortKey="Reuss, A" sort="Reuss, A" uniqKey="Reuss A" first="A" last="Reuss">A. Reuss</name><affiliation wicri:level="1"><nlm:affiliation>AGO, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>AGO, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Bacon, M" sort="Bacon, M" uniqKey="Bacon M" first="M" last="Bacon">M. Bacon</name><affiliation wicri:level="1"><nlm:affiliation>GCIG, Kingston, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>GCIG, Kingston</wicri:regionArea><wicri:noRegion>Kingston</wicri:noRegion></affiliation></author><author><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. Friedlander</name><affiliation><nlm:affiliation>ANZGOG, Sydney, Australia-New Zealand.</nlm:affiliation><wicri:noCountry code="subField">Australia-New Zealand</wicri:noCountry></affiliation></author><author><name sortKey="Gallardo Rincon, D" sort="Gallardo Rincon, D" uniqKey="Gallardo Rincon D" first="D" last="Gallardo-Rincon">D. Gallardo-Rincon</name><affiliation wicri:level="1"><nlm:affiliation>GICOM, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>GICOM</wicri:regionArea></affiliation></author><author><name sortKey="Joly, F" sort="Joly, F" uniqKey="Joly F" first="F" last="Joly">F. Joly</name><affiliation wicri:level="3"><nlm:affiliation>GINECO, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GINECO, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chang, S J" sort="Chang, S J" uniqKey="Chang S" first="S-J" last="Chang">S-J Chang</name><affiliation wicri:level="1"><nlm:affiliation>KGOG, Suwon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>KGOG, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Ferrero, A M" sort="Ferrero, A M" uniqKey="Ferrero A" first="A M" last="Ferrero">A M Ferrero</name><affiliation wicri:level="3"><nlm:affiliation>ManGO, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ManGO, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name><affiliation wicri:level="1"><nlm:affiliation>MRC/NCRI, Gateshead, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC/NCRI, Gateshead</wicri:regionArea><wicri:noRegion>Gateshead</wicri:noRegion></affiliation></author><author><name sortKey="Wimberger, P" sort="Wimberger, P" uniqKey="Wimberger P" first="P" last="Wimberger">P. Wimberger</name><affiliation wicri:level="3"><nlm:affiliation>NOGGO, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>NOGGO, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Maenpaa, J" sort="Maenpaa, J" uniqKey="Maenpaa J" first="J" last="Maenpaa">J. Maenpaa</name><affiliation><nlm:affiliation>NSGO, Copenhagen, Scandinavia.</nlm:affiliation><wicri:noCountry code="subField">Scandinavia</wicri:noCountry></affiliation></author><author><name sortKey="Gaffney, D" sort="Gaffney, D" uniqKey="Gaffney D" first="D" last="Gaffney">D. Gaffney</name><affiliation wicri:level="1"><nlm:affiliation>RTOG, Salt Lake City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>RTOG, Salt Lake City</wicri:regionArea><wicri:noRegion>Salt Lake City</wicri:noRegion></affiliation></author><author><name sortKey="Zang, R" sort="Zang, R" uniqKey="Zang R" first="R" last="Zang">R. Zang</name><affiliation wicri:level="1"><nlm:affiliation>SGOG, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>SGOG, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Okamoto, A" sort="Okamoto, A" uniqKey="Okamoto A" first="A" last="Okamoto">A. Okamoto</name><affiliation wicri:level="3"><nlm:affiliation>JGOG, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>JGOG, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Stuart, G" sort="Stuart, G" uniqKey="Stuart G" first="G" last="Stuart">G. Stuart</name><affiliation wicri:level="1"><nlm:affiliation>CCTG, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>CCTG, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Ochiai, K" sort="Ochiai, K" uniqKey="Ochiai K" first="K" last="Ochiai">K. Ochiai</name><affiliation wicri:level="3"><nlm:affiliation>JGOG, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>JGOG, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Humans</term><term>Neoplasm Recurrence, Local (therapy)</term><term>Ovarian Neoplasms (pathology)</term><term>Ovarian Neoplasms (therapy)</term><term>Research Design</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Plan de recherche</term><term>Récidive tumorale locale ()</term><term>Tumeurs de l'ovaire ()</term><term>Tumeurs de l'ovaire (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Neoplasm Recurrence, Local</term><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Research Design</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Plan de recherche</term><term>Récidive tumorale locale</term><term>Tumeurs de l'ovaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This manuscript reports the consensus statements regarding recurrent ovarian cancer (ROC), reached at the fifth Ovarian Cancer Consensus Conference (OCCC), which was held in Tokyo, Japan, in November 2015. Three important questions were identified: (i) What are the subgroups for clinical trials in ROC? The historical definition of using platinum-free interval (PFI) to categorise patients as having platinum-sensitive/resistant disease was replaced by therapy-free interval (TFI). TFI can be broken down into TFIp (PFI), TFInp (non-PFI) and TFIb (biological agent-free interval). Additional criteria to consider include histology, BRCA mutation status, number/type of previous therapies, outcome of prior surgery and patient reported symptoms. (ii) What are the control arms for clinical trials in ROC? When platinum is considered the best option, the control arm should be a platinum-based therapy with or without an anti-angiogenic agent or a poly (ADP-ribose) polymerase (PARP) inhibitor. If platinum is not considered the best option, the control arm could include a non-platinum drug, either as single agent or in combination. (iii) What are the endpoints for clinical trials in ROC? Overall survival (OS) is the preferred endpoint for patient cohorts with an expected median OS < or = 12 months. Progression-free survival (PFS) is an alternative, and it is the preferred endpoint when the expected median OS is > 12 months. However, PFS alone should not be the only endpoint and must be supported by additional endpoints including pre-defined patient reported outcomes (PROs), time to second subsequent therapy (TSST), or time until definitive deterioration of quality of life (TUDD).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>Italie</li><li>Japon</li><li>Mexique</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>District de Dresde</li><li>Piémont</li><li>Région de Kantō</li><li>Saxe (Land)</li><li>Île-de-France</li></region><settlement><li>Dresde</li><li>Paris</li><li>Tokyo</li><li>Turin</li></settlement></list><tree><noCountry><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. Friedlander</name><name sortKey="Maenpaa, J" sort="Maenpaa, J" uniqKey="Maenpaa J" first="J" last="Maenpaa">J. Maenpaa</name><name sortKey="Mirza, M R" sort="Mirza, M R" uniqKey="Mirza M" first="M R" last="Mirza">M R Mirza</name><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name><name sortKey="Wilson, M K" sort="Wilson, M K" uniqKey="Wilson M" first="M K" last="Wilson">M K Wilson</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name></region><name sortKey="Joly, F" sort="Joly, F" uniqKey="Joly F" first="F" last="Joly">F. Joly</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Aoki, D" sort="Aoki, D" uniqKey="Aoki D" first="D" last="Aoki">D. Aoki</name></region><name sortKey="Ochiai, K" sort="Ochiai, K" uniqKey="Ochiai K" first="K" last="Ochiai">K. Ochiai</name><name sortKey="Okamoto, A" sort="Okamoto, A" uniqKey="Okamoto A" first="A" last="Okamoto">A. Okamoto</name></country><country name="Italie"><noRegion><name sortKey="Lorusso, D" sort="Lorusso, D" uniqKey="Lorusso D" first="D" last="Lorusso">D. Lorusso</name></noRegion><name sortKey="Ferrero, A M" sort="Ferrero, A M" uniqKey="Ferrero A" first="A M" last="Ferrero">A M Ferrero</name></country><country name="Canada"><noRegion><name sortKey="Oza, A M" sort="Oza, A M" uniqKey="Oza A" first="A M" last="Oza">A M Oza</name></noRegion><name sortKey="Bacon, M" sort="Bacon, M" uniqKey="Bacon M" first="M" last="Bacon">M. Bacon</name><name sortKey="Stuart, G" sort="Stuart, G" uniqKey="Stuart G" first="G" last="Stuart">G. Stuart</name></country><country name="Allemagne"><noRegion><name sortKey="Du Bois, A" sort="Du Bois, A" uniqKey="Du Bois A" first="A" last="Du Bois">A. Du Bois</name></noRegion><name sortKey="Reuss, A" sort="Reuss, A" uniqKey="Reuss A" first="A" last="Reuss">A. Reuss</name><name sortKey="Wimberger, P" sort="Wimberger, P" uniqKey="Wimberger P" first="P" last="Wimberger">P. Wimberger</name></country><country name="Mexique"><noRegion><name sortKey="Gallardo Rincon, D" sort="Gallardo Rincon, D" uniqKey="Gallardo Rincon D" first="D" last="Gallardo-Rincon">D. Gallardo-Rincon</name></noRegion></country><country name="Corée du Sud"><noRegion><name sortKey="Chang, S J" sort="Chang, S J" uniqKey="Chang S" first="S-J" last="Chang">S-J Chang</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Gaffney, D" sort="Gaffney, D" uniqKey="Gaffney D" first="D" last="Gaffney">D. Gaffney</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Zang, R" sort="Zang, R" uniqKey="Zang R" first="R" last="Zang">R. Zang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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